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A small molecule inhibitor blocks breast cancer's back up plan

A small molecule inhibitor blocks breast cancer's back up plan

Scientists discovered a long sought-after inhibitor for the DNA repair polymerase, Polθ, which may be key to treating drug-resistant BRCA1 and BRCA2-mutant cancers.

A promising new class of psychotropic drugs

A promising new class of psychotropic drugs

A newly developed drug stabilizes dopamine and serotonin levels using a novel mechanism. It effectively treats psychosis in patients with schizophrenia, and researchers are testing its efficacy for Parkinson’s disease as well.

COVID-19 may trigger an autoimmune response

COVID-19 may trigger an autoimmune response

Researchers plan to monitor the immune responses of COVID-19 patients for one year to see how they correlate with illness severity and lasting effects. This data will help develop personalized treatments for patients.

Activating a brain circuit relieves pain in male mice, but not in female mice

Activating a brain circuit relieves pain in male mice, but not in female mice

Scientists identified a new sex-specific pain circuit in the brain, laying the groundwork for developing better pain-relieving drugs for both sexes.

Can a probiotic prevent type 1 diabetes in children?

Can a probiotic prevent type 1 diabetes in children?

An upcoming clinical study will test whether a B. infantis probiotic can prevent the development of type 1 diabetes in predisposed infants.

A promising protein degrader trashed a key oncogenic protein

A promising protein degrader trashed a key oncogenic protein

Targeting oncogenic transcription factors like MYC is challenging, but researchers found a way to target its regulator, WDR5, for degradation, exemplifying the capacity of protein degraders to target the “undruggable.”
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• Volume 17 • Issue 6 • June 2021

June 2021

June 2021 issue