Cancer

Researchers are tapping into the potential of noncoding RNA in the blood to enhance cancer diagnostics. 

As cell therapy evolves rapidly, what advancements are on the horizon? 

Researchers showed that pancreatic cancer stem cells produce a protein usually made by neutrophils to evade the immune system and keep growing.

Profiling over 100,000 genomes, researchers identified rare mutations associated with early menopause and cancer, and that some mutations pass down to children.

Effective target identification is central to drug discovery, but finding the right drug target is not as simple as it may seem in theory. 

An innovative sample storage system enables efficient, eco-friendly biorepository management. 

Detecting tumor antigens is key to developing effective cancer diagnostics, immunotherapies, and vaccines.

Cowpea mosaic virus stimulated the immune system to treat and prevent metastatic cancers in mice.

Manish Sharma led a clinical trial for a new antibody-drug conjugate that decreased tumor size in patients who had not responded to chemotherapy.

Breast cancer cells can pass through the bone marrow to reach the tissues surrounding the brain and spinal cord in mice — a new way for cancer to spread.

A new mouse study suggests that folinic acid treatment could help the immune system penetrate pancreatic cancer’s protective shell.

Bacteria can invade colorectal cancer tumors, leading to worse disease outcomes. Oxygen — or lack thereof — plays a vital role in this interaction.

Avoiding skin cancer could be as easy as slathering on a gel that the body rapidly metabolizes.

A new technique boosts the sensitivity of mass cytometry to allow detection and characterization of low-abundance markers, yielding new disease insights.

Natural killer cells can sometimes attack beneficial CAR T cell immunotherapies. Now, researchers have discovered why and a potential way to stop them.

Two review papers consolidate 30 years of research.

An inhibitory receptor binds a checkpoint protein to thwart T cell proliferation and function.

Cancer cells with mutated p53 undergo apoptosis by stalling ribosomes at rare leucine codons, inhibiting protein translation.

Researchers develop sensitive blood-based diagnostics to detect tiny traces of cancer. 

3D bioprinted models of the tumor microenvironment could make the preclinical research process more reliable and accelerate translation to the clinic.