N-cadherins in smooth muscle cells play an important role in constricting bronchi, but inhibiting the protein could provide relief to patients with asthma.
Sagimet’s denifanstat delivered significant improvements in disease activity and fibrosis for patients with metabolic dysfunction-associated steatohepatitis.
A compound that inhibits replication of the dengue virus in mammals was similarly effective in mosquitoes consuming it via blood, reducing transmissibility.
Two mutations in the BRCA1 gene greatly increase the risk of breast cancer. Now, it seems that only one mutation can help cells tip toward a cancerous edge.
A small percentage of cells in healthy breast tissue show chromosomal abnormalities often linked to cancer, a finding with potential diagnostic implications.