Incretin-based therapies have significantly shifted clinical approaches to managing obesity, yet the underlying tissue-specific molecular changes remain an active area of investigation. Uncovering how these systemic interventions alter biological pathways across multiple organ systems requires integrating deep phenotyping with global molecular analyses.
In this webinar, Crystal West and Joshua Justice will discuss how combining in-life phenotyping, histopathology, and systems-scale proteomics in a diet-induced obesity (DIO) model provides a comprehensive framework to map therapeutic outcomes to distinct cellular mechanisms.
Topics to be covered:
- How DIO models capture key metabolic features of human obesity
- Systems-scale proteomic changes across tissues, with a focus on skeletal muscle metabolism
- Exploring how new obesity drugs may reverse tissue dysfunction, improve insulin resistance, and restore cellular energy metabolism
- Analyzing how obesity and treatment impact muscle health and physical function
Tuesday, August 11th 2026 | 11:00 AM – 12:30 PM Eastern Time
This webinar will be available to view live and on demand.
Speakers
Crystal West, PhD
Associate Director, Cardiometabolic Diseases
Inotiv
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Joshua Justice, PhD
Proteomics Scientist
Inotiv
