Infectious Disease & Vaccines

In vivo studies of the antibiotic darobactin D22 against high-priority gram-negative bacteria show promise for further drug development.

Bacteria from healthy vaginas show promise in protecting women from pathogens, but advancing their development requires more funding and research.

A compound that inhibits replication of the dengue virus in mammals was similarly effective in mosquitoes consuming it via blood, reducing transmissibility. 

Sulopenem becomes the first oral penem antibiotic approved in the United States, expanding non-IV treatment options for UTIs.

In some kids, an RSV infection is mild, while others are hospitalized. Natural killer cells might be the reason why.

Structural analysis of the herpes simplex virus polymerase revealed that mutations affecting its drug binding and flexibility may drive treatment resistance.

Gut microbes can protect or sensitize each other to drugs, even to non-antibiotics.

A new vaccination schedule pumps up the immune response to human immunodeficiency virus, overcoming a barrier that has frustrated vaccine designers.

As scientific output grows, the risk of a promising drug getting lost increases, but advances in artificial intelligence and machine learning may prevent that.

Bacteria’s constant interaction with viruses has led them to evolve antiviral strategies.

Rhinoviruses, the main cause of the common cold, are unique among respiratory viruses.

Doctors have been treating bacterial vaginosis with the same antibiotic for decades. This fatty acid could change that.

Engineered peptides that mimic molecules of the innate immune system act synergistically with available drugs to treat Candida albicans in an animal model.

Microparticle injections containing an immunomodulator protein inhibited bone loss and promoted repair in a mouse model of periodontal disease.

Merck researchers developed an effective vaccine against pneumococcal diseases.

In a mix of innovation and accident, researchers developed a new antibiotic that has broad efficacy across Gram-positive bacteria.

Proteins from intracellular pathogens can help expel drugs delivered by macrophages.

There is no vaccine against this parasitic worm infection, but rhesus macaques’ unique immune system has brought the prospect of a vaccine closer than ever.

Scientists developed an unprecedented chemical tool to visualize sphingomyelin and sphingomyelinase activity during a chlamydia infection.

Organ-on-a-chip technology can replicate the cervix microenvironment in bacterial vaginosis.