Traditional two-dimensional (2D) cell cultures are simple and scalable, but they often fail to replicate the complexity of native tissue environments. Phenotypic three-dimensional (3D) cell models better capture cell-cell interactions, cell-matrix interactions, and tissue architecture, providing more biologically relevant systems. for studying disease biology and evaluating therapeutic candidates. Successfully adopting 3D models requires careful consideration of model selection, matrix choice, culture workflows, and downstream analytical methods.
This eBook provides a roadmap for adopting phenotypic 3D cell models and outlines practical considerations for selecting, generating, and analyzing scalable 3D cultures to support drug discovery research.
Download this eBook to learn:
- How to select appropriate 3D models and matrix materials
- Practical considerations for creating and scaling 3D cell cultures
- Approaches for imaging, assays, and downstream data analysis
