Transporting osteoarthritis drugs to the joints is challenging. Innovations in nanoparticle delivery, therapeutic gels, and “smart cells” may be the answer.
Researchers simultaneously increased the potency of a cancer drug while reducing both the required dose and the side effects, all by using a surprising new drug delivery vehicle: bacteria.
Nanoparticles fuse with cells to deliver their gene or RNA therapy cargo, but some are better shuttles than others. Now, scientists have developed a way to find the best nanoparticles for the job.
Nanoparticles that successfully deliver drugs in mice often fail in humans. To understand how nanoparticles fare across different model species, scientists developed a high-throughput system to screen nanoparticles in mice with humanized livers with the hope of better predicting nanoparticles that work in humans.
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