Uncovering the mysterious antidepressant effects of ketamine
Ketamine effectively treats depression, but recent studies illustrate the ongoing difficulties in understanding its antidepressant effects at a molecular level.
Articles by Andrew Saintsing, PhD
Seeing into the future of autism detection
A new app relies on smartphone cameras and algorithms to check for signs of neurodivergence in children.
The search for new antibiotics goes macrocyclic
Zosurabalpin, a macrocyclic peptide, kills drug resistant Acinetobacter baumannii bacteria by blocking cross-membrane transport.
Keeping minerals out of veins
Inhibiting a single protein may prevent cardiovascular complications in patients with chronic kidney disease.
Pigs provide a better model for Batten disease
A new porcine model for the rare neurological disorder CLN3 Batten disease more faithfully recreates human symptoms and could accelerate drug development.
A touch of toxic gas could power health
Although harmful in large quantities, hydrogen sulfide may ameliorate the health consequences of aging when small doses are applied to the mitochondria.
Correcting for tuberculosis susceptibility
Using a machine learning approach, researchers discovered how to make mouse macrophages resistant to tuberculosis infection.
Helping the brain stop neurodegeneration
A small molecule called ALGERNON2 improved health outcomes in mouse models of neurodegenerative diseases by activating antioxidant pathways in astrocytes.
The future of chemotherapy clicks into place
Selective labeling of cancer stem cells with click chemistry-capable functional groups offers a new strategy for anticancer drug delivery.
What foraging teaches about mental health
Investigating the neural and molecular pathways that help foragers decide when to look for better resources could lead to new ways to treat mental health conditions.
