A 3D illustration of protein molecules floating in a dark blue background

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Lloyd Smith

A picture of Sam Markovitch and Brian Frey in the Lloyd Smith laboratory operating a mass spectrometer

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Achieving higher accuracy and depth in bottom-up proteomics involves navigating a multifaceted process with various steps and challenges.

Expert Advice: Fulfilling the potential of bottom-up proteomics

Articles

Headshot of Shawn Li from Western University

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Interleukin 5 is produced by T helper cells. It stimulates B cell growth, increases immunoglobulin secretion and mediates eosinophil activation

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Image of a hand holding a multiplexed sample.

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An ingenious chemical labeling strategy offers solutions to enhancing throughput in mass spectrometry analysis.

Expert Advice: Unlocking efficiency in proteomics with TMT labeling

Colorful chain of amino acids or bio molecules called proteins - 3d illustration

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A diagram showing the workflow of tandem mass tag mass spectrometry.

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Top considerations for TMT mass spectrometry analysis

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December 2025

3D illustration of a membrane protein embedded within a lipid nanodisc, representing a native-like environment used for membrane protein stabilization and characterization.

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Refeyn

Mass photometry supports membrane protein characterization by providing rapid insights into sample composition, purity, and molecular assembly.

Characterizing nanodisc-embedded membrane proteins

Application Note

3D illustration of a protein complex composed of clustered spherical subunits arranged in a ring-like oligomeric structure, shown in shades of blue, cyan, and purple against a blue gradient background.

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Automated mass photometry helps reveal the complex dynamics of protein oligomerization and the factors that govern protein assembly.

Understanding protein oligomerization with mass photometry

A 3D rendering illustrates a sandwich ELISA technique, where antigen detection is achieved between two layers of antibodies: a capture antibody and a detection antibody

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R&D Systems by Bio Techne

Learn the key characteristics that determine whether an immunoassay generates accurate and reproducible data.

tandem mass spectrometry

Expert Advice: Fulfilling the potential of bottom-up proteomics

Expert Advice: Unlocking efficiency in proteomics with TMT labeling

Top considerations for TMT mass spectrometry analysis

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December 2025