Cell atlases have mapped human biology in unprecedented detail. The harder question for drug discovery is which of those cellular states should change what a program does next.
The novel stem-cell derived retinal organoid provided a new understanding of the disease by showing that damage to retinal pigment epithelium cells is enough to cause neurodegeneration of photoreceptors.
Rodrigo Cristofoletti discusses how cerebral organoids, advanced imaging, and quantitative modeling are helping researchers better understand brain development, disease, and drug discovery.
Dehydrodolichyl diphosphate synthase (DHDSS)-related disease has no available treatments. The new work could finally change that with nicotinamide mononucleotide (NMN).
As drug discovery adopts more human-relevant models and complex biologics, it’s increasingly important that reagents are more consistent, better characterized, and fit for purpose.
After decades of slow progress, advances in molecular profiling and organoid technology are creating new pathways for non-invasive diagnosis and targeted treatment of endometriosis.
Explore how dual binding assays reveal interactions between bispecific antibodies and their targets, providing insights into binding behavior and antibody function.