September 2018- Volume 14, Issue 9

In this Issue

Business & Government Policy

Patent Docs: Allergan, a Mohawk tribe and the USPTO

Patent Docs: Allergan, a Mohawk tribe and the USPTO

Federal Circuit decision addresses dispute between Allergan and the St. Regis Mohawk Tribe, tackling the issue of sovereign immunity

X-SCID expertise

X-SCID expertise

Mustang Bio and St. Jude enter license agreement

Reducing cancer trial barriers

Reducing cancer trial barriers

Two research organizations submit recommendations to FDA aimed at greater patient participation in trials

On the cutting edge

On the cutting edge

A roundup of instrumentation, software and other tools and technology news

It’s all in the delivery

It’s all in the delivery

Checking out the news in drug delivery advancements

Q&A

Q&A: SK Life Science and the central nervous system

Q&A: SK Life Science and the central nervous system

We speak with Dr. Marc Kamin, chief medical officer of SK Life Science, about the company and CNS disorder therapeutics

Research & Development

Tuning in to stereochemistry

Tuning in to stereochemistry

Scripps, Bristol-Myers Squibb scientists reveal a method to control thiophosphate linkages in nucleosides

Decoding how living tissues get their flexibility

Decoding how living tissues get their flexibility

MIT study reveals atomic structure of tropoelastin, showing what goes wrong in some diseases

Biomarker for breast cancer

Biomarker for breast cancer

Researchers identify a histone that could have significance in treating aggressive breast cancer

Double the sequencing

Double the sequencing

Mount Sinai combines DNA and RNA sequencing to pinpoint treatment options for multiple myeloma patients

Sustaining a market edge

Sustaining a market edge

MilliporeSigma, InnoCore enter into agreement to provide SynBiosys biodegradable polymer platform

Discovery

CMPK2 inhibitors vs. chronic inflammation

CMPK2 inhibitors vs. chronic inflammation

Blocking CMPK2 enzyme could mean relief for a host of conditions

Blocking alcohol addiction and easing withdrawal

Blocking alcohol addiction and easing withdrawal

Scripps Research scientists find novel pathway in the receptor GPR139

Immatics and Genmab partner on next-gen cancer immunotherapies

Immatics and Genmab partner on next-gen cancer immunotherapies

Companies combine proprietary tech to create bispecific therapies against novel tumor targets

Back to the beginning

Back to the beginning

Cells reverting to ‘fetal program’ may accelerate wound healing

New data about the presence of prions

New data about the presence of prions

The identification of prion-like domains in multiple viral strains points to new areas to explore

Diagnostics

The earlier, the better

The earlier, the better

Precision’s Epiontis ID diagnostic detects many rare, severe immune diseases in newborns

HeadsUp for cystic fibrosis

HeadsUp for cystic fibrosis

Study to assess biomarkers associated with onset of pulmonary problems and validate diagnostic for self-monitoring

Predicting checkpoint blocker response

Predicting checkpoint blocker response

Study finds melanoma biomarkers that could help in tailoring immunotherapy

Accurate annotations

Accurate annotations

Bicoastal startup launches NGS product for pathogen detection

Clinical Trials

Mogamulizumab makes a mark

Mogamulizumab makes a mark

Kyowa Kirin announces results of Phase 3 clinical study published in Lancet Oncology

Out of the starting gate

Out of the starting gate

A roundup of clinical trial startups and initial breakthroughs

Zogenix announces positive results for ZX008 in Dravet syndrome

Zogenix announces positive results for ZX008 in Dravet syndrome

Statistically significant convulsive seizure reduction seen, and all key secondary endpoints met

Initial exuberance overshadowed by doubt

Initial exuberance overshadowed by doubt

Promising results from Alzheimer’s drug wither under closer scrutiny
Conquering Crohn’s disease

Conquering Crohn’s disease

Conquering Crohn’s disease

Promising Phase 3 test results give hope for those with the gastrointestinal disorder

Preclinical

Good news for Siamab with Stn

Good news for Siamab with Stn

New antigen target shows promise against ovarian cancer

Article elucidates ITI-214’s mechanism of action

Article elucidates ITI-214’s mechanism of action

Modulation of adenosine A2B receptor signaling pathway increases cardiac contractility without increasing intracellular calcium

Making the (pre)clinical rounds

Making the (pre)clinical rounds

A collection of news of recently published papers

Certis partners with Reveal Biosciences

Certis partners with Reveal Biosciences

Duo will offer advanced preclinical oncology services

Commentary

Guest commentary: DNA sequencing is cancer’s next frontier

Guest commentary: DNA sequencing is cancer’s next frontier

Guest commentary: DNA sequencing is cancer’s next frontier

In the quest for personalized medicine to become reality, next-generation sequencing is key

Out of order: Just being social

Out of order: Just being social

We’ve put a greater emphasis on our social media presence lately, and you might want to do the same if you haven’t already, not to mention visit us online

Contract Services

Catalent snaps up Juniper Pharmaceuticals

Catalent snaps up Juniper Pharmaceuticals

$133-million deal adds European Early Development Center of Excellence to global network

Riding the Seventh Wave to future growth

Riding the Seventh Wave to future growth

BASi acquires Missouri-based contract lab Seventh Wave, expanding service offerings, doubling clients

LifeSci launches LifeSci Strategic Partnering and Analytics

LifeSci launches LifeSci Strategic Partnering and Analytics

New offering will give clients expertise and assistance in business development and market analytics

Feature

Editor's Focus

Editor’s focus: A ‘personalized’ problem in the public space

Editor’s focus: A ‘personalized’ problem in the public space

Way too many people in the United States still don’t know what personalized medicine is, and that’s a problem we need to overcome before the misinformation creeps in too much
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