February 2021 Volume 17, Issue 2

February 2021 cover

Volume 17, Issue 2 | February 2021

February 2021

In this Issue

Discovery

Rekindling an Old Flame: Targeting tumors with bacteria

Bacteria have proven to be essential partners in everyday life, but can they also treat cancer?

Could Siglec-12 cause cancers to advance?

People who produce this protein may be at twice the risk for advanced cancer

Scientists map structure of potent antibody against coronavirus

Computer-generated images show why immune protein neutralizes SARS-CoV-2

InveniAI and Kyowa Kirin partner on target discovery

The companies have expanded an existing collaboration to find novel targets

Preclinical

Introducing NGM438

NGM438 is an antagonist antibody that inhibits LAIR1

Talking about a resolution

Data show that OSE-230 can resolve chronic inflammation

HCA with 3D models

InSphero-Yokogawa partnership will support drug development research

Out with the old, in with the new

New cancer immunotherapy shows promise in treating cancer

Clinical Trials

Extending a new breast cancer option with ExteNET

Extending a new option with ExteNET

Puma reports that neratinib improved CNS outcomes in HER2-positive breast cancer patients
Ibrexafungerp advances the fight against fungus

Ibrexafungerp advances the fight against fungus

IV compound enters Phase 1, following FDA Priority Review and Fast Track designations for oral formulation
Intratumoral therapy

Intratumoral therapy

Plasmid DNA delivery platform looks promising for metastatic melanoma therapy
Chimerix acquires Oncoceutics

Chimerix acquires Oncoceutics

Move will expand Chimerix pipeline with late-stage oncology program

Diagnostics

AI is put to work on NASH biomarkers

AI is put to work on NASH biomarkers

iBiopsy study shows promise in diagnosing severity of disease in patients
Ingestible capsule offers in-depth diagnostics

Ingestible capsule offers in-depth diagnostics

Progenity presents results on PIL Dx capsule in small intestinal bacterial overgrowth

Tools & Technology

Drug dissolution solution

Drug dissolution solution

Researchers develop method of assessing time-release drugs
A cHAT about chemistry

A cHAT about chemistry

Rice University chemists detail a greener way to make pharmaceutical intermediates
A helping hand from Hemibody

A helping hand from Hemibody

MorphoSys licenses Hemibody technology from Cherry Biolabs in hopes of improving T cell-based therapeutics

Special Reports

Special Report on Natural Products: Mining metabolites

Rebirth of an industry requires reinvention

Editor's Focus

Infectious disease research is a triathlon

Dealing with viruses, bacteria and other pathogens requires many approaches

A great leap from clinical trials to clinical practice

There is potential for better tying clinical practice to clinical trials, but when will we get there?

Feature

Focus Feature on Vaccines

mRNA approaches vs. SARS-CoV-2, plus more news of infectious disease and cancer vaccines

Commentary

Commentary: How can multiplex immunoassays support vaccine development?

Well-established assay formats that can be used throughout the development continuum are  a great benefit to researchers
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Laboratorian with a white coat and blue gloves pipettes green liquid into a beaker with multicolored liquids in beakers and tubes in the blue-tinged, sterile laboratory background.

Discovering cutting-edge nitrosamine analysis in pharmaceuticals

New tools help researchers detect and manage harmful nitrosamine impurities in drugs such as monoclonal antibodies.
A starry night sky reflected over calm water, symbolizing the discovery of hidden patterns in complex systems.

Technology Guide: Spatial biology techniques

Discover essential strategies and expert insights to navigate the expanding world of spatial biology.
Red tumor cells are shown against a teal backdrop showing attachment to tissue.

Decoding the tumor microenvironment with immune profiling

Integrating multiplexed immunohistochemistry with spatial analysis offers a practical way to uncover tumor-immune dynamics.
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