February 2021- Volume 17, Issue 2

In this Issue

Commentary

Commentary: How can multiplex immunoassays support vaccine development?

Commentary: How can multiplex immunoassays support vaccine development?

Well-established assay formats that can be used throughout the development continuum are  a great benefit to researchers

Editor's Focus

Infectious disease research is a triathlon

Infectious disease research is a triathlon

Dealing with viruses, bacteria and other pathogens requires many approaches

A great leap from clinical trials to clinical practice

A great leap from clinical trials to clinical practice

There is potential for better tying clinical practice to clinical trials, but when will we get there?

Feature

Focus Feature on Vaccines

Focus Feature on Vaccines

mRNA approaches vs. SARS-CoV-2, plus more news of infectious disease and cancer vaccines

Discovery

Rekindling an Old Flame: Targeting tumors with bacteria

Rekindling an Old Flame: Targeting tumors with bacteria

Bacteria have proven to be essential partners in everyday life, but can they also treat cancer?

Could Siglec-12 cause cancers to advance?

Could Siglec-12 cause cancers to advance?

People who produce this protein may be at twice the risk for advanced cancer

InveniAI and Kyowa Kirin partner on target discovery

InveniAI and Kyowa Kirin partner on target discovery

The companies have expanded an existing collaboration to find novel targets

Preclinical

Introducing NGM438

Introducing NGM438

NGM438 is an antagonist antibody that inhibits LAIR1

Talking about a resolution

Talking about a resolution

Data show that OSE-230 can resolve chronic inflammation

HCA with 3D models

HCA with 3D models

InSphero-Yokogawa partnership will support drug development research

Out with the old, in with the new

Out with the old, in with the new

New cancer immunotherapy shows promise in treating cancer

Clinical Trials

Ibrexafungerp advances the fight against fungus

Ibrexafungerp advances the fight against fungus

IV compound enters Phase 1, following FDA Priority Review and Fast Track designations for oral formulation

Extending a new option with ExteNET

Extending a new option with ExteNET

Puma reports that neratinib improved CNS outcomes in HER2-positive breast cancer patients

Intratumoral therapy

Intratumoral therapy

Plasmid DNA delivery platform looks promising for metastatic melanoma therapy

Chimerix acquires Oncoceutics

Chimerix acquires Oncoceutics

Move will expand Chimerix pipeline with late-stage oncology program

Diagnostics

AI is put to work on NASH biomarkers

AI is put to work on NASH biomarkers

iBiopsy study shows promise in diagnosing severity of disease in patients

Ingestible capsule offers in-depth diagnostics

Ingestible capsule offers in-depth diagnostics

Progenity presents results on PIL Dx capsule in small intestinal bacterial overgrowth

Tools & Technology

Drug dissolution solution

Drug dissolution solution

Researchers develop method of assessing time-release drugs

A cHAT about chemistry

A cHAT about chemistry

Rice University chemists detail a greener way to make pharmaceutical intermediates

A helping hand from Hemibody

A helping hand from Hemibody

MorphoSys licenses Hemibody technology from Cherry Biolabs in hopes of improving T cell-based therapeutics
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