Oral bioavailability, or how much of a drug reaches the bloodstream after being taken by mouth, is a critical factor in drug development. Yet, traditional lab and animal models don’t always reflect what happens in the human body. Microphysiological system (MPS) models that combine absorption and metabolism by the gut with metabolism in the liver can be used to determine pharmacokinetic parameters, such as bioavailability, more accurately and in vitro. In this webinar, Marco Ortiz and Morné van Wyk will discuss how a gut/liver MPS, or gut/liver-on-a-chip, combined with in silico simulations, helps predict drug absorption and metabolism more accurately, offering a more human-relevant approach to preclinical studies.
Topics to be covered:
- Leveraging MPS and in silico modeling to predict up to 10 gut- and liver-specific pharmacokinetic parameters from a single experiment
- The benefits of using primary human cells in lab-grown gut and liver MPS models
- A unique step-by-step guide to estimating oral bioavailability by profiling absorption and metabolism by the gut and liver
Speakers
Marco Ortiz, PhD
Senior Scientist
CN Bio
Morné van Wyk, PhD
Senior Computational Scientist, Biology
CN Bio
