Drug-induced liver injury (DILI) is a major cause of late-stage drug attrition, resulting from diverse mechanisms, such as oxidative stress, mitochondrial dysfunction, and immune-mediated responses. Traditional in vitro models often lack physiological relevance, while animal studies fail to fully capture human-specific liver responses. New liver microphysiological systems enable researchers to detect complex hepatotoxicity pathways, providing deeper mechanistic insights to reduce clinical risk.
Download this application note to learn:
- How advanced liver microphysiological models help spot early signs of liver damage
- The role of immune and metabolic interactions in DILI development
- How human-relevant in vitro systems bridge the gap between traditional preclinical models and clinical outcomes
