Predicting drug-induced toxicity before compounds reach the clinic remains a major challenge in drug development. Traditional models often fail to predict human responses, contributing to late-stage failures and safety risks. Human-relevant three-dimensional (3D) tissue models provide an approach for assessing toxicity across multiple organs simultaneously, helping identify potential safety liabilities earlier and inform development decisions.
This research poster presents an integrated multi-organ toxicity workflow using 3D human liver, kidney, and intestinal tissue models in a 96-well format to assess compound safety in a physiologically relevant system. By combining live-cell imaging with functional and molecular readouts, it enables time-resolved, organ-specific characterization of dose-dependent toxicity and compound-specific response profiles.
Download this research poster to learn:
- How 3D human tissue models enable parallel assessment of liver, kidney, and intestinal toxicity
- How real-time imaging reveals dose-dependent and organ-specific toxicity responses
- How 3D human tissue models support new approach methodologies and animal-sparing toxicity testing strategies
