Analyzing metal-sensitive compounds in high-performance liquid chromatography remains challenging due to interactions with metallic components, leading to signal loss and higher variability — especially for electron-rich analytes. Advances in surface chemistry help reduce these interactions, improving peak shape, sensitivity, and reproducibility for drug discovery.
Download this whitepaper to learn:
- How metal‑analyte interactions affect peak shape, recovery, and reproducibility across liquid chromatography workflows
- Why system and column surface chemistry both matter when analyzing metal‑sensitive compounds
- How low‑adsorption surfaces improve sensitivity and precision, particularly for low‑level analytes
- Real application examples showing improved performance for nucleotides, oligonucleotides, acidic peptides, and pharmaceutical compounds
