An illustration of genetic engineering with CRISPR/Cas9, a powerful tool for gene editing that may cause off-target effects if used without molecular safety switches.
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Safety buttons for CRISPR/Cas9

New technologies keep CRISPR/Cas9 in check and minimize off-target risks.

CRISPR/Cas9 enables precise genetic modifications that may solve an array of diseases, but off-target CRISPR/Cas9 activity could lead to unintended mutations and risks such as organ damage or immunogenicity. Scientists are developing various safety switches, such as anti-CRISPRs and high-fidelity Cas9s, to enhance the precision and reliability of this transformative technology. 

Download this poster from Drug Discovery News to learn about innovative strategies to improve CRISPR/Cas9’s safety profile and reduce the risk of off-target effects.

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