Traditional chromatographic workflows can be time-consuming, solvent-intensive, and limited in selectivity. Supercritical fluid chromatography (SFC) uses CO₂ in its supercritical state as the mobile phase, combining liquid-like solvating power with gas-like diffusivity to overcome these challenges. Laboratories under pressure to accelerate method development while reducing costs and environmental impact need more flexible and efficient solutions.
Download this compendium to learn:
- How supercritical CO₂ enables faster separations with lower solvent consumption
- Practical strategies for column screening, modifier selection, and backpressure optimization
- How to improve sensitivity, reduce matrix effects, and scale from analytical to preparative workflows
