Traditional animal models remain an important part of preclinical research, but species differences can limit translation of findings to human biology. New approach methodologies (NAMs), including human cell-based models, three-dimensional tissues, microphysiological systems, preserved human tissues, and computational approaches, provide complementary ways to investigate disease mechanisms and drug responses.
This eBook explores how integrated NAMs can generate human-relevant evidence in drug development, covering emerging models, computational approaches, and key considerations for their application and adoption.
Download this eBook to learn:
- How cardiac NAMs capture electrophysiological and tissue-level responses
- How human brain models complement organoids, computational approaches, and animal studies
- Challenges in validating and integrating human-relevant preclinical models
