Targeted protein degradation relies on productive interactions between degraders, E3 ubiquitin ligases, and recruited neosubstrates. Understanding how these interactions are regulated and distinguishing binding events from downstream degradation can provide deeper insight into degrader activity and selectivity.
In this webinar, Vanessa Dippon and Tomas Friman will discuss the discovery of a cryptic allosteric pocket on cereblon, its effects on ligand binding and neosubstrate degradation, and the use of the Cellular Thermal Shift Assay (CETSA) coupled to mass spectrometry to profile degrader binding interactions and selectivity in intact cells.
Topics to be covered:
- Discovery and structural characterization of an allosteric cereblon pocket
- Effects of cereblon allostery on ligand binding and neosubstrate degradation
- Cellular profiling of degrader binding interactions and selectivity using CETSA
- Comparison of PROTAC and molecular glue degrader activity
Wednesday, November 11th 2026 | 11:00 AM – 12:30 PM Eastern Time
This webinar will be available to view live and on demand.
Speakers
Vanessa Dippon, PhD
Postdoctoral Fellow
Broad Institute of MIT and Harvard
Tomas Friman, PhD
Principal Scientist, R&D
Pelago Bioscience
