Lipid nanoparticles (LNPs) have transformed nucleic acid delivery, yet directing these systems to specific tissues and cell types introduces new layers of complexity. Achieving precise biodistribution, efficient intracellular delivery, and reproducible manufacturing requires careful control over formulation, process parameters, and analytical characterization.
This compendium captures key insights from an expert-led webinar and related conference content. It highlights the formulation, analytical, chemistry, and manufacturing choices that can help targeted LNP programs progress toward investigational new drug submission.
Download the compendium to learn:
- Five practical decisions that determine whether a targeted LNP reaches the clinic
- What new ionizable lipid chemistries are enabling lymphoid and extra-hepatic delivery, including in vivo CAR T applications
- How to design analytical strategies that hold up under good manufacturing practice requirements
