The push toward new approach methodologies is converging on the same expectation: nephrotoxicity data should come from systems that behave like a human kidney, with structure and transporter expression that hold up over weeks.
This application note tests a human proximal tubule model by dosing it side-by-side with cisplatin and oxaliplatin. Although these two compounds are structurally similar, the model tracks their toxicity profiles diverging live.
Download this application note to explore how:
- The model separates toxicity thresholds by sevenfold
- Fluorescence and standard viability assays part ways at different doses
- Cisplatin exposure reshapes tubule structure
