Selecting promising biologic candidates requires more than evaluating target binding affinity and biological activity. Molecular stability, pharmacokinetic properties, binding kinetics, and functional responses can influence a candidate's suitability for further development. Combining computational analysis with biophysical and cell-based assays enables a more comprehensive assessment of these attributes during early-stage discovery.
This collection of scientific posters examines early-stage developability assessments, surface plasmon resonance (SPR) characterization, and in vitro functional evaluation, illustrating how complementary analytical approaches support lead screening, characterization, and optimization.
Download these posters to learn:
- How computational and biophysical assessments identify developability risks related to aggregation, nonspecific binding, stability, and pharmacokinetic properties
- How SPR enables characterization of binding affinity, kinetics, receptor interactions, and epitope diversity during lead selection and optimization
- How in vitro assays evaluate the functional activity of antibody-drug conjugates, T cell engagers, and therapeutic antibodies targeting autoimmune and inflammatory diseases
