Xenon inks $184 million cardiovascular disease collaboration with Merck

VANCOUVER, British Columbia—On June 11, Xenon announced a strategic alliance with Merck & Co. Inc., through an affiliate, to discover and develop novel small-molecule candidates for the potential treatment of cardiovascular disease. In collaboration with Merck, Xenon will perform validation studies using its clinical genetics platform, as well as drug discovery and select preclinical development of small molecule compounds for those targets selected by a joint steering committee. Under the terms of the agreement, Merck has the option to exclusively license targets and compounds from Xenon for development and commercialization. In return, Xenon receives research funding and is eligible for option exercise fees, research, development and regulatory milestone payments of up to $94.5 million for the first target and up to $89.5 million for each subsequent target selected for drug discovery. In addition, Merck will pay Xenon undisclosed royalties on sales of products resulting from the collaboration. Xenon retains the right to develop and commercialize certain compounds for which Merck does not exercise its option.