White Papers

Download this application note from PHC Corporation of North America to learn how 3D cell culture more closely models in vivo conditions and captures clinically relevant results. 

Quantitative reverse transcription PCR (RT-qCR) involves the detection and quantification of RNA. The process is performed by reverse transcription of the enzyme reverse transcriptase, followed by amplification and detection of the specific targets of this DNA using a technique called quantitative PCR (qPCR) or real-time PCR.  

Determining Nanoparticle Vaccine Construct Design Stability and Antigenic Efficiency by Improving Nanoparticle Vaccine Design with BLI.

Eppendorf performed fed-batch cultures using BioBLU® 1c and 3c Single-Use Vessels controlled in parallel by the new SciVario® twin bioreactor control system.

Fragment-based lead discovery is establishing itself as valuable approach for the discovery of novel small molecule leads. It relies on establishing a better understanding of the binding mechanism of a ligand for its binding partner by probing for “hot spots “on the protein target with small molecule fragments (typically <300 Daltons). Its simplicity is in the principle of building a pharmacophore from the ground up. Successful selection requires data on binding affinity as well as extensive SAR information provided by a variety of techniques . . .

Using the Cytation™3 Cell Imaging Multi-Mode Reader to Monitor IL-6 Secretion Using HTRF Detection and Cell Viability Using Digital Widefield Fluorescence Microscopy

In flow cytometry and fluorescence microscopy (including high content screening), a reliable estimation of cell viability is important because it is central to assays for apoptosis and in vitro toxicology. Likewise, it is a measure ... (click for more)

KINOME WIDE PROFILING AND SCREENING SOLUTIONS COUPLED TO FUNCTIONAL CELL-BASED ASSAYS ENABLE LAUNCH OF SELECTIVE AND FUNCTIONAL KINASE INHIBITORS