White Papers

The Need for a PARP in vivo Pharmacodynamic Assay

2nd Generation PARP in vivo Pharmacodynamic Assay: In this article we present information regarding Trevigen’s 2nd Generation PARP Pharmacodynamic Assay. We provide validation data and accelerated shelf life data regarding key assay components for the new assay format which features: a 96 well assay plate pre-coated with PAR capture antibody, extended dynamic range, and high signal to noise ratios.


Fragment-based lead discovery is establishing itself as valuable approach for the discovery of novel small molecule leads. It relies on establishing a better understanding of the binding mechanism of a ligand for its binding partner by probing for “hot spots “on the protein target with small molecule fragments (typically <300 Daltons). Its simplicity is in the principle of building a pharmacophore from the ground up. Successful selection requires data on binding affinity as well as extensive SAR information provided by a variety of techniques . . .

Retinoid Receptors: Overview and Tools for Researchers

Retinoids are a class of chemical compounds related to vitamin A. The two predominant and most studied retinoids are all-trans retinoic acid (ATRA) (the acid form of vitamin A also known as Tretinoin) and 9-cis-retinoic acid (9-cis RA or Alitretinoin). Retinoids have many important and diverse functions throughout the body, including roles....

The Effect of Cell Culture Method on Long-Term Primary Hepatocyte Cell Health

Cytation™ 3 Cell Imaging Multi-Mode Microplate Reader Cytation™ 3 is a cell imaging multi-mode microplate reader that combines automated digital microscopy and conventional microplate detection. This patent pending design provides phenotypic cellular information with well-based intensity data. MultiFlo™ FX Microplate Dispenser MultiFlo FX is a modular reagent dispenser for 6- to 1536-well plates, dispensing volumes as low as 500 nL. An available wash module adds multi-purpose functionality.
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• Volume 17 • Issue 2 • February 2021

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