Traditional tools for assessing oral drug bioavailability such as cell lines and animal models struggle to reflect human physiology, often leading to inaccurate predictions and costly setbacks. Without integrated modeling of intestinal absorption and hepatic metabolism, it’s nearly impossible to simulate the complexity of first-pass metabolism. In this webinar, Yassen Abbas and Elizabeth Boazak describe the construction and validation of a primary human gut-liver microphysiological system (MPS) to overcome these challenges.
Topics to be covered:
- Engineering a gut-liver MPS to model human drug metabolism
- Why this model improves prediction of drugs’ oral bioavailability
- What test results reveal about its performance versus traditional systems
