Technology Guide: Purifying and desalting macromolecules

Understanding the potential pitfalls of molecular dialysis and implementing solutions is crucial for ensuring efficient and effective sample purification. 

Antibody, protein, and nucleic acid purification often rely on molecular dialysis to eliminate unwanted substances and contaminants. This traditionally involves sealing the sample in a dialysis membrane with clamps, soaking it in a buffer, and stirring for hours to days. However, mishaps like loose clamps, inadequate membrane area to sample volume ratios, and improper buffer stirring can slow process times and lead to sample loss and lingering impurities.

Download this Technology Guide from Vivaproducts to learn about innovative solutions for overcoming common molecular dialysis challenges and achieving faster purification of macromolecules. 

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