With videos of dramatic cancer cell deaths and unflagging T cell attacks, Alex Ritter studies how immune cells and tumors battle with microscopic precision.
While some pediatric brain cancers have known genetic causes, many do not. Three-dimensional profiling revealed new disease mechanisms and drug targets.
Scientists discovered that healthy epithelial cells recognize their precancerous neighbors via the expression of proteins normally only found on immune cells. The proteins that mediate this recognition between healthy and precancerous cells provide a potential new therapeutic avenue for treating cancer.
In children, T cells effectively combat acute infections such as COVID-19, but a new study in mice suggests that the T cell response is detrimental when fighting pediatric tumors.
Immunotherapy was a game-changer for the cancer field, but immunotherapies using cytokines like IL-2 often cause severe side effects. Researchers are developing a newly engineered blueprint to improve the therapeutic efficacy and safety of IL-2 and other cytokines.
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