In the top left, an atomic force microscopy image of a group of light brown TRPV3 ion channels against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer. In the bottom left, a cryogenic electron microscopy structure of the tetramer with the four subunits shown in yellow, green, orange and purple. In the bottom right, a cryogenic electron microscopy structure of the pentamer with the five subunits shown in yellow, green, orange, purple, and pink. 

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On the left, an atomic force microscopy image of a group of light brown TRPV3 ion channels is shown against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer is shown. 

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Microscopy images reveal the structural change that enlarges an ion channel pore, opening new directions in drug discovery and delivery.

Zooming in on pore dilation

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Zooming in on pore dilation

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