A 3D rendition of two neurons and their electrical connections.

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A light blue colored HCN1 channel sits in the plasma membrane with orange colored propofol shown engaging the channel.

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The general anesthesia drug propofol restores function to mutated signaling channels associated with epilepsy.

Repurposing an anesthetic for epilepsy

News

Marnie Fusco, Erica Ollmann Saphire, and Sharon Schendel standing inside a scientific lab with a microscope in the middle 

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A 3D render of the measles virus’s green fusion protein floating with antibodies attached to it in blue. 

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Researchers uncovered the structure of the measles fusion glycoprotein and identified a neutralizing antibody capable of decreasing its virulence.

Visualizing the measles virus reveals a potential treatment

Illustration of the four levels of protein structure, including primary, secondary, tertiary, and quaternary structure

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A 3D rendering showing a drug molecule bound to a protein, with the protein depicted as a cartoon model and the drug as a ball-and-stick model

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A flowchart illustrating the overall approach to computational protein structure prediction, starting with a protein sequence and progressing through multiple sequence alignment, database searching, secondary structure prediction, protein threading, homology modeling, and  Ab initio modeling to generate a 3D protein model, with steps varying based on the presence of homologs in the PDB and prediction results.

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The cryo-EM structure of a protein is depicted in ribbon and surface representations, with different colors highlighting individual domains within the structures.

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A cartoon representation of a protein binding to a small molecule at the protein’s binding site 

An image of protein crystals used for X-ray crystallography

A cartoon representation of a zinc finger motif of proteins

How do scientists utilize protein structural information to create therapeutic agents efficiently?

Structure-based drug design

Articles

A person wearing a white glove holds a plate of white bacterial colonies on red agar.

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Ben Tresco and Kelvin Wu from Andrew Myers laboratory sit on a couch and hold a chemical model of one of their synthetic antibiotics.

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Fully synthetic approaches expand the repertoire of possible antimicrobials to overcome existing antibiotic resistance mechanisms.

A new synthetic antibiotic tightly binds bacterial ribosomes

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March 2025

A person wearing a white lab coat types on a laptop with various overlaid enlarged files shown with plus signs on file folders floating over the laptop screen with a clinical lab shown in the background in grey and white tones.

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Thermo Fisher Scientific

Learn how researchers can improve compliance and efficiency with advanced LIMS solutions.

Enhancing bioanalytical studies with centralized data management

Whitepaper

A 3D-rendered digital illustration of a molecular structure floating among red blood cells in a bloodstream environment.

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Takara Bio

By offering a rich source of insights into disease and drugs, metabolite biomarkers are at the forefront of therapeutic exploration.

Explained: How are metabolite biomarkers improving drug discovery and development?

Explainers

Clear cells with round, blue centers are shown against a varied blue background

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Bio-Techne

Researchers can enhance efficiency, yield, and consistency in clonal cell line development with specialized tools.

structural biology