Illustration of the four levels of protein structure, including primary, secondary, tertiary, and quaternary structure

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A 3D rendering showing a drug molecule bound to a protein, with the protein depicted as a cartoon model and the drug as a ball-and-stick model

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A flowchart illustrating the overall approach to computational protein structure prediction, starting with a protein sequence and progressing through multiple sequence alignment, database searching, secondary structure prediction, protein threading, homology modeling, and  Ab initio modeling to generate a 3D protein model, with steps varying based on the presence of homologs in the PDB and prediction results.

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The cryo-EM structure of a protein is depicted in ribbon and surface representations, with different colors highlighting individual domains within the structures.

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A cartoon representation of a protein binding to a small molecule at the protein’s binding site 

An image of protein crystals used for X-ray crystallography

A cartoon representation of a zinc finger motif of proteins

How do scientists utilize protein structural information to create therapeutic agents efficiently?

Structure-based drug design

Articles

An illustration showing colorful protein structures on a dark blue background. 

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A photo of Demis Hassabis wearing a red sweater on a white background

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A photo of John Jumper outdoors wearing a gray striped T-shirt.

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Demis Hassabis and John Jumper received the Albert Lasker Basic Medical Research Award for developing technology that predicts the 3D structures of proteins.

AlphaFold developers honored with the 2023 Lasker Award

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March 2025

A blue x-ray style image of a human body is shown with the liver illuminated in orange against a dark blue background.  

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CN Bio

Discover how researchers leverage microphysiological systems in toxicology studies. &nbsp;

Harnessing liver-on-a-chip models for drug safety

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Thermo Fisher Scientific

Learn how researchers can improve compliance and efficiency with advanced LIMS solutions.

Enhancing bioanalytical studies with centralized data management

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A 3D-rendered digital illustration of a molecular structure floating among red blood cells in a bloodstream environment.

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Takara Bio

By offering a rich source of insights into disease and drugs, metabolite biomarkers are at the forefront of therapeutic exploration.

protein structure

Structure-based drug design

AlphaFold developers honored with the 2023 Lasker Award

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Harnessing liver-on-a-chip models for drug safety

Enhancing bioanalytical studies with centralized data management

Explained: How are metabolite biomarkers improving drug discovery and development?

March 2025