Illustration of the four levels of protein structure, including primary, secondary, tertiary, and quaternary structure

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A 3D rendering showing a drug molecule bound to a protein, with the protein depicted as a cartoon model and the drug as a ball-and-stick model

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A flowchart illustrating the overall approach to computational protein structure prediction, starting with a protein sequence and progressing through multiple sequence alignment, database searching, secondary structure prediction, protein threading, homology modeling, and  Ab initio modeling to generate a 3D protein model, with steps varying based on the presence of homologs in the PDB and prediction results.

binding

The cryo-EM structure of a protein is depicted in ribbon and surface representations, with different colors highlighting individual domains within the structures.

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A cartoon representation of a protein binding to a small molecule at the protein’s binding site 

An image of protein crystals used for X-ray crystallography

A cartoon representation of a zinc finger motif of proteins

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An illustration showing colorful protein structures on a dark blue background. 

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A photo of Demis Hassabis wearing a red sweater on a white background

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A photo of John Jumper outdoors wearing a gray striped T-shirt.

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Demis Hassabis and John Jumper received the Albert Lasker Basic Medical Research Award for developing technology that predicts the 3D structures of proteins.

AlphaFold developers honored with the 2023 Lasker Award

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November 2024

A 3D illustration of purple-colored cancer cells surrounded by transparent immune cells with yellow nuclei

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Software innovations help researchers decode immune complexity in cancer.

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An abstract digital representation of data fabric and artificial intelligence

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Excelra

Mastering data preparation is key to harnessing the full potential of advanced computational tools.

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An illustration showing a DNA strand and scientists removing segments with tweezers, representing the CRISPR gene editing technology 

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Emerging CRISPR screening methods are shaping what&rsquo;s possible in drug development and precision medicine.

protein structure

Structure-based drug design

AlphaFold developers honored with the 2023 Lasker Award

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