Sumita Bhatta, who is involved in the Sjögren’s disease drug development at Amgen, wears a dark blazer outside against a green background.

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A woman with black curly hair and glasses rubs her eye.

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As a CD40 ligand antagonist, dazodalibep blocks immune cell communication, potentially serving as the first drug to target the autoimmune disease&rsquo;s cause.

Amgen drug blocks immune chitchat that drives Sj&ouml;gren&rsquo;s disease

News

Illustration of the four levels of protein structure, including primary, secondary, tertiary, and quaternary structure

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A 3D rendering showing a drug molecule bound to a protein, with the protein depicted as a cartoon model and the drug as a ball-and-stick model

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A flowchart illustrating the overall approach to computational protein structure prediction, starting with a protein sequence and progressing through multiple sequence alignment, database searching, secondary structure prediction, protein threading, homology modeling, and  Ab initio modeling to generate a 3D protein model, with steps varying based on the presence of homologs in the PDB and prediction results.

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The cryo-EM structure of a protein is depicted in ribbon and surface representations, with different colors highlighting individual domains within the structures.

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A cartoon representation of a protein binding to a small molecule at the protein’s binding site 

An image of protein crystals used for X-ray crystallography

A cartoon representation of a zinc finger motif of proteins

How do scientists utilize protein structural information to create therapeutic agents efficiently?

Structure-based drug design

Articles

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March 2025

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Thermo Fisher Scientific

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Clear sample tubes are shown in a clear tote with red lids in a sample prep robot with a blue and silver industrial lab background.

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Discover how better sample preparation can unlock improved assay accuracy and analytical results.

The crucial role of sample preparation in biotherapy manufacturing

Webinars

A black mosquito is shown on pink human skin against a blurred green backdrop. 

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Embrient

Malaria continues to drive urgent research worldwide, with new therapies and tools emerging to combat the parasite&rsquo;s complex lifecycle and global burden.

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Amgen drug blocks immune chitchat that drives Sjögren’s disease

Structure-based drug design

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