For the first time, researchers observed new conformational states between opioid drugs binding to mu opioid receptors — findings that drug developers can use to design safer opioid drugs.
Researchers identified a peptide that selectively blocks pain signaling in sensory neurons and packaged it into a viral-based gene therapy in a step towards treating chronic pain without the risk for addiction.
Seeking alternatives to pharmacological approaches, researchers apply thermal, electrical, and mechanical stimuli to change nerve signaling and treat pain.
Explore how emerging in vitro systems — built from primary cells, cocultures, and vascularized tissues — are improving translational research outcomes.