The intricate design of a fundamental filter protein
A collaboration of nephrologists and biochemists created the first structure of “megalin,” a critical protein in kidney and brain disorders.
News
Aging dogs provide insights for human longevity
Biogerontologist Matt Kaeberlein studies aging pets to determine how to improve healthspan in dogs and their humans.
Targeting nutrient signaling in the gut to tackle metabolic disease
A new oral bead technology is designed to stimulate nutrient-sensing cells in discrete parts of the gut to restore metabolic balance.
New genetic pathways involved in aging
By analyzing the changing genomes of short- and long-lived rockfish, scientists identified a new set of genes that might alter lifespan.
Restoring memory with the help of young cerebrospinal fluid
Researchers identified a component of cerebrospinal fluid that improved memory in old mice, potentially opening the door to drug development.
Arming bacteria with diarrhea-fighting nanobodies
By engineering a probiotic with tiny antibodies from alpacas, scientists created a potential new oral tool to treat deadly diarrheal infections.
Engineering fertility options for cancer survivors
Aiming to preserve fertility for women undergoing cancer treatments, researchers are developing biomaterials that mimic the structure and function of the ovary.
Switching on safer CAR T cell therapy
By activating CAR T cells only in the presence of an antibody switch, Travis Young and his team hope to make this cancer treatment safer and more effective.
Animals build social relationships without oxytocin receptors
Prairie voles without oxytocin receptors showed surprisingly normal social behaviors, raising questions about the underpinnings of sociality.
How the brain rewards pleasurable physical touch
Using optogenetics, neurobiologists traced a stimulating physical touch from the skin all the way to the reward center of the brain for the first time.
