neurodegeneration

A gene therapy targeting organs beyond the brain could improve quality of life and possibly extend survival in children with the neurodegenerative disease.

New gene therapies in clinical trials seek to treat Alzheimer’s disease and heal the brain with a dose of helpful genetic material.

Scores of neurons are already dead by the time Parkinson’s disease is usually diagnosed. Scientists aim to identify patients earlier and intervene before it’s too late.

Scientists imaged new communication pathways between the skull and the brain and uncovered immune responses exclusive to the skull.

By watching brain organoids develop, researchers observed surprising abnormalities caused by mutations in a gene related to early-onset Alzheimer’s disease.

Brain organoids serve as avatars for studying human neurobiology and advancing drug discovery for neurological disorders. 

Slight modifications to glycoproteins reveal critical insights into disease onset, state, and progression, making them a wellspring for biomarker discovery. 

A small molecule called ALGERNON2 improved health outcomes in mouse models of neurodegenerative diseases by activating antioxidant pathways in astrocytes.

From reducing prion protein to fighting neuroinflammation, researchers try different techniques to combat deadly prion diseases.

A one-time gene therapy aims to stop Huntington's disease at its source. But first, it has to survive clinical trials.