neurodegeneration

Scores of neurons are already dead by the time Parkinson’s disease is usually diagnosed. Scientists aim to identify patients earlier and intervene before it’s too late.

Scientists imaged new communication pathways between the skull and the brain and uncovered immune responses exclusive to the skull.

By watching brain organoids develop, researchers observed surprising abnormalities caused by mutations in a gene related to early-onset Alzheimer’s disease.

Brain organoids serve as avatars for studying human neurobiology and advancing drug discovery for neurological disorders. 

Slight modifications to glycoproteins reveal critical insights into disease onset, state, and progression, making them a wellspring for biomarker discovery. 

A small molecule called ALGERNON2 improved health outcomes in mouse models of neurodegenerative diseases by activating antioxidant pathways in astrocytes.

From reducing prion protein to fighting neuroinflammation, researchers try different techniques to combat deadly prion diseases.

A one-time gene therapy aims to stop Huntington's disease at its source. But first, it has to survive clinical trials.

Data from a highly resilient individual guided researchers to new potential therapeutic targets.  

A new form of brain stimulation treatment that responds to a patient’s brain activity could be life changing for people with neurological and psychiatric disorders.