Researchers in George Church’s lab modified wild type ADK proteins (left) in <em>E.coli</em>, furnishing them with an nonstandard Amino Acid (nsAA) meant to biocontain the resulting bacterial strain.

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Akos Nyerges uses MAGE to genetically protect E. coli from invading phages and prevent those modified genes from escaping into the environment.

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Several cycles of MAGE can introduce edited segments of genetic information to multiple targets in a genome, as well as promote the growth of a diverse population of cells in a colony or swap out amino acids in polypeptide chains.

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SSAPs work with a host’s existing single-strand binding proteins to edit single-strand portions of DNA. Using SSAPs to bind edited genes during replication produces a new generation of edited cells, which can be scaled up using the MAGE system.

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

A pioneer of the multiplex frontier

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