functional genomics

A detailed 3D image of cells alongside a DNA helix structure.

| 3 min read

ByBree Foster, PhD

Inherited genes could help make CAR T therapies safer and more effective

Analysis of two pivotal Yescarta clinical trials revealed that patients' germline DNA influences both toxicity risk and CAR T expansion, opening new opportunities for smarter cell therapy design.

Hands wearing protective gloves hold blue-stained electrophoresis gel with separated proteins.

| 4 min read

ByArchie Lawhorne

How researchers are overcoming assay limitations in protein analysis

The rise of iPSC-derived immune cells and CRISPR-based engineering is reshaping functional genomics, but protein-level validation has struggled to keep pace.

3D illustration of a CRISPR-Cas9 genome editing enzyme.

Available on Demand

CRISPR-based screens for drug discovery

Genome-wide CRISPR screens in living organisms reveal mechanisms that cell culture studies overlook.

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3D illustration of a single cell surrounded by small molecular particles in a red biological environment.

Mapping cancer signaling at single cell resolution

Measuring mRNA and protein together at single cell resolution can uncover tumor-specific signaling activity and immune features.

Application Note

Illustration of an antibody intertwined with a DNA double helix.

Mapping immune disease variants at genome scale

Discover how CRISPR and single-cell RNA sequencing can connect disease-associated variants to regulatory elements, genes, and pathways.

Digital illustration of the human digestive system highlighting the liver, stomach, and intestines.

From absorption to metabolism: predicting human oral drug exposure

Explore how human gut-liver models can improve the translation of preclinical findings into clinical pharmacokinetic predictions.