EXN407 is the first topical SRPK1 inhibitor to demonstrate safety and efficacy as a monotherapy for non-proliferative diabetic retinopathy (NPDR) and diabetic macular oedema.
Plummeting blood sugar can accelerate eye damage due to diabetes. Results in mice suggest that a new drug targeting hypoxia inducible factor could help.
In diabetic macular edema, senescent cells build up in the retina, leading to vision loss. A new drug forces these undead cells to die, healing the retina.
James Fujimoto, Eric Swanson, and David Huang developed optical coherence tomography, which transformed ophthalmological practice and spurred new imaging applications.
Explore how emerging in vitro systems — built from primary cells, cocultures, and vascularized tissues — are improving translational research outcomes.