A 3D illustration of herpes simplex virus in yellow against a blue background.

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A 3D protein structure image showing the HSV polymerase with different protein domains labeled and color-coded.

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Structural analysis of the herpes simplex virus polymerase revealed that mutations affecting its drug binding and flexibility may drive treatment resistance.

Protein conformation may have a hand in herpes drug resistance

News

A 3D rendition of two neurons and their electrical connections.

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A light blue colored HCN1 channel sits in the plasma membrane with orange colored propofol shown engaging the channel.

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The general anesthesia drug propofol restores function to mutated signaling channels associated with epilepsy.

Repurposing an anesthetic for epilepsy

In the top left, an atomic force microscopy image of a group of light brown TRPV3 ion channels against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer. In the bottom left, a cryogenic electron microscopy structure of the tetramer with the four subunits shown in yellow, green, orange and purple. In the bottom right, a cryogenic electron microscopy structure of the pentamer with the five subunits shown in yellow, green, orange, purple, and pink. 

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On the left, an atomic force microscopy image of a group of light brown TRPV3 ion channels is shown against a black background with white arrow heads pointing to a tetramer and pentamer. In the top right, a close up atomic force microscopy image of the tetramer and pentamer is shown. 

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Microscopy images reveal the structural change that enlarges an ion channel pore, opening new directions in drug discovery and delivery.

Zooming in on pore dilation

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December 2025

White laboratory mouse standing in a petri dish in a laboratory, illustrating a rodent model commonly used in scientific and preclinical studies.

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Inotiv

Learn about common challenges and proper maintenance practices for catheterized rodent models.

Post-surgical management strategies for reliable preclinical rodent studies

Webinars

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Revvity Signals

Learn why data quality, governance, and collaboration are critical to realizing AI&rsquo;s potential across the drug discovery pipeline.

Building stronger AI foundations for drug discovery&nbsp;

Articles

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Hands typing on an open laptop, viewed from above, against a colorful gradient background with abstract geometric network patterns.

Explore how electronic lab notebooks strengthen data integrity, collaboration, and reproducibility across today&rsquo;s research environments.

cryogenic electron microscopy

Protein conformation may have a hand in herpes drug resistance

Repurposing an anesthetic for epilepsy

Zooming in on pore dilation

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December 2025