Illustration of the four levels of protein structure, including primary, secondary, tertiary, and quaternary structure

c4680951-650a-4382-ba27-659cd0309c6b

A 3D rendering showing a drug molecule bound to a protein, with the protein depicted as a cartoon model and the drug as a ball-and-stick model

e6687a91-aa14-46c7-a305-eccea17444dd

A flowchart illustrating the overall approach to computational protein structure prediction, starting with a protein sequence and progressing through multiple sequence alignment, database searching, secondary structure prediction, protein threading, homology modeling, and  Ab initio modeling to generate a 3D protein model, with steps varying based on the presence of homologs in the PDB and prediction results.

binding

The cryo-EM structure of a protein is depicted in ribbon and surface representations, with different colors highlighting individual domains within the structures.

csiro-scienceimage-418-xray-crystallography-protein-crystals

A cartoon representation of a protein binding to a small molecule at the protein’s binding site 

An image of protein crystals used for X-ray crystallography

A cartoon representation of a zinc finger motif of proteins

How do scientists utilize protein structural information to create therapeutic agents efficiently?

Structure-based drug design

Articles

Pink, spherical viral particles float across a dark background.

istock-1205880056-1800x900

Researchers defined the structure of key Nipah virus proteins to develop vaccines and treatments for this deadly virus.

Mapping Nipah viral architecture to prevent a new pandemic

News

An orange rod-shaped bacterium with blue flagella.

1800x900-istock-1336571183

A picture of the authors of the Nature paper. From left to right, Filippo Mancia, Khuram Ashraf, and Rie Nygaard.

mancia

A new understanding of one enzyme&rsquo;s role in assembling a key macromolecule in the bacterial cell wall takes a step toward overcoming antibiotic resistance.&nbsp;

A potential new target for developing antibiotics

1-0325-cover

March 2025

Surface rendering of two interacting proteins (green and peach) bound together by a small molecule ligand at their interface, illustrating a protein-ligand binding event.

untitled-2

primary-lockup-p-500-1-64e0fe115-1

Salad Technologies

Learn how molecular dynamics, AI-aided design, and structural insights combine to reshape how therapeutic proteins are created, validated, and optimized.

Computational approaches to drug design

Compendium

Stem cells are shown as clear, purple, and blue spheres against a dark blue and black background.

article

Diagram showing how patient-derived somatic cells are reprogrammed into iPSCs using Yamanaka factors and then differentiated into specialized cell types such as neurons, cardiomyocytes, and hepatocytes.

ips-cells-image

BPS Bioscience

Human-relevant, ready-to-use stem cell models are reshaping drug discovery, toxicity testing, and personalized medicine.

Improving translational research with iPSC-derived cells

mike-heaven-phd

Characterizing lipid nanoparticles for RNA therapeutic development

205c4df9-5f8b-4936-b768-3f926ab08bbc

Inotiv

Integrated multiomics and advanced nanoparticle analytics are improving how researchers perform RNA delivery, increasing therapeutic success.

CryoEM

Structure-based drug design

Mapping Nipah viral architecture to prevent a new pandemic

A potential new target for developing antibiotics

Subscribe to our eNewsletters

Sponsored

March 2025