cancer therapy resistance

With so many cancer patients not responding to these immunotherapies, researchers are looking for new ways to boost their efficacy.

Autophagy in cancer is a double-edged sword: It protects cells from malignant transformation, but once tumors form, it helps them thrive.

Judy Sebolt-Leopold and her team at MEKanistic Therapeutics developed a single molecule targeting two kinase enzymes that drive resistance to cancer therapies.

An experimental drug significantly reduced tumor burden and extended survival in mice with pancreatic cancer.

Antibodies that simultaneously target two distinct antigens overcome cancer therapy resistance by addressing antigenic diversity and diminished T cell action.