antibiotics

Antibiotics target bacteria, but new work in mice shows they also harm the mucus layer that protects the intestinal lining from microbes.

New phenotypic methods can help identify the best antibiotic to treat sepsis, UTIs, and other bacterial infections.

In vivo studies of the antibiotic darobactin D22 against high-priority gram-negative bacteria show promise for further drug development.

Sulopenem becomes the first oral penem antibiotic approved in the United States, expanding non-IV treatment options for UTIs.

Gut microbes can protect or sensitize each other to drugs, even to non-antibiotics.

As scientific output grows, the risk of a promising drug getting lost increases, but advances in artificial intelligence and machine learning may prevent that.

In a mix of innovation and accident, researchers developed a new antibiotic that has broad efficacy across Gram-positive bacteria.

Plectasin forms dense structures on bacterial membranes by binding to unique lipids in bacterial cell walls.

Biofilms render most antibiotics ineffective, but ultrasound may be the key to clearing these chronic infections.

Could the solution to antibiotic resistance already have been discovered? Microbiologists and historians probe medieval and ancient texts to find out.