Alzheimer's disease

By watching brain organoids develop, researchers observed surprising abnormalities caused by mutations in a gene related to early-onset Alzheimer’s disease.

Young blood rejuvenates aging organs in rodents. Researchers are studying the potential to use young blood-based treatments in aging humans too.

Activating specific neurons using light helped scientists establish a causal link between improved sleep and diminished signs of Alzheimer’s disease in mice.

Slight modifications to glycoproteins reveal critical insights into disease onset, state, and progression, making them a wellspring for biomarker discovery. 

A small molecule called ALGERNON2 improved health outcomes in mouse models of neurodegenerative diseases by activating antioxidant pathways in astrocytes.

A dementia-associated tau mutation promotes unusual clustering of Fyn, a protein important for learning and memory.

A collaboration of nephrologists and biochemists created the first structure of “megalin,” a critical protein in kidney and brain disorders.

By analyzing the changing genomes of short- and long-lived rockfish, scientists identified a new set of genes that might alter lifespan.

Drugs that target senescent cells could one day treat frailty, Alzheimer’s disease, or cancer.

The Alzheimer's disease research field has been beset by failed clinical trials and fraud. But researchers remain hopeful that a better understanding of the disease’s broader picture will lead to treatments.