For the first time, researchers observed new conformational states between opioid drugs binding to mu opioid receptors — findings that drug developers can use to design safer opioid drugs.
Vertex Pharmaceuticals’ drug, Journavx, blocks a sodium channel outside of the brain. Experts hope that this non-addictive pain drug may be the first of many.
No pharmaceutical treatments exist for addictions to drugs like cocaine or cannabis. Now, scientists are engineering gene therapies, immunotherapies, and more.
Researchers discovered that microbial short chain fatty acids influence drug seeking behavior in rats, revealing potential new therapeutic targets for cocaine use disorder.
Explore how emerging in vitro systems — built from primary cells, cocultures, and vascularized tissues — are improving translational research outcomes.