Stem cells and screening

Ncardia seeks to bring human disease biology earlier into drug discovery and development

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LEIDEN, the Netherlands—Early February saw Ncardia, a provider of human induced pluripotent stem cell (iPSC)-derived cell-based assays and services for drug discovery and development, announce the launch of their DiscoverHIT drug screening platform. The new service enables researchers to access human disease-relevant biology earlier in the drug discovery process with the goal of bringing better medicines to patients faster. The DiscoverHIT Platform is a phenotypic drug screening platform composed of four integrated modules:
  • Disease models: Genetic and induced human iPSC-derived cardiac and neural disease models
  • Large-scale manufacturing: Controlled bioreactor-based manufacturing to enable batch sizes compatible with high-throughput screening (HTS)
  • Customized assay development: Generation and validation of disease-relevant assays with clinically relevant readouts
  • High-throughput screening: Robust HTS using qualified disease assays in combination with high content data acquisition and analysis.
“Ncardia enables discovery with efficacy in mind from the start. To realize this, drug developers need validated human iPSC products at scale, disease models, the right assay systems and high-throughput screening. We’ve brought these components together in the DiscoverHIT platform,” said Stefan Braam, CEO of Ncardia.
In addition to the four core modules of DiscoverHIT, Ncardia also offers access to a comprehensive compound library, scientific consultation and the company’s newly founded training center, Ncardia Academy.

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