Misfolded and aggregated proteins underlie many neurodegenerative diseases, yet traditional drug design often struggles to target these dynamic structures. Combining structural biology, cryo-electron microscopy, and chemical biology, researchers are now discovering small molecules capable of interacting with amyloid fibrils and driving their breakdown.
In this webinar, Paul Seidler will discuss how he develops small molecules that self-assemble into suprastructures to dismantle pathogenic protein aggregates, offering a new perspective on therapeutic strategies for neurodegenerative proteinopathies.
Topics to be covered:
- Mechanisms of amyloid fibril disassembly
- Role of small molecule suprastructures in targeting protein aggregates
- Integration of medicinal chemistry, cheminformatics, and screening approaches
- Implications for developing therapies for neurodegenerative diseases
Thursday, March 12th, 2026 | 11:00 AM – 12:00 PM Eastern Time
This webinar will be available to view live and on demand.
Speaker
Paul Seidler, PhD
Assistant Professor
University of Southern California
Supported by
