Editing the cell’s transcripts
For cases where gene editing simply won’t work, biochemist Aseem Ansari is working on a new idea: changing how cells regulate genes.
Rare & Genetic Diseases
A pioneer of the multiplex frontier
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Gene editing: DNA versus RNA
Researchers correcting the genetic causes of disease at the DNA or RNA level make their cases.
From dye to base editing, early aging may soon have a cure
Kan Cao studies the rare aging disorder progeria to find a cure, and she’s ready to solve the mysteries of healthy human aging along the way.
A new gene therapy for inherited blindness
Neuroscientists safely delivered a critical gene that improved vision for two patients with Leber congenital amaurosis.
Sequencing 100,000 genomes to revolutionize Nigerian genomics
With diseases like cancer and kidney disease on the rise in Africa, Segun Fatumo and his team are sequencing the genomes of 100,000 Nigerians to understand why.
Copper triggers a unique form of cell death
Researchers discovered that copper induces cytotoxicity through a distinct pathway termed cuproptosis. This insight guides the use of copper-shuttling drugs to treat copper regulation disorders and opens up new therapeutic applications for cancer.
Addressing sex differences in autoimmune diseases
Susan Kovats explores the role of sex hormones in autoimmunity to guide the development of therapeutics for lupus, Sjögren’s syndrome, and other diseases that preferentially affect women.
Manipulating nerves to relieve pain without drugs
Seeking alternatives to pharmacological approaches, researchers apply thermal, electrical, and mechanical stimuli to change nerve signaling and treat pain.
A silk cocoon gives a protective shell to oral drugs in the gut
Researchers are harnessing the power of silk to develop a shelf- and digestive tract-stable enzyme treatment for phenylketonuria.
