PPMD launches Newborn Screening Pilot

PPMD partners with New York State in hopes that early diagnosis will lead to early interventions for Duchenne

DDNews Staff
Register for free to listen to this article
Listen with Speechify
HACKENSACK, N.J.—Parent Project Muscular Dystrophy (PPMD) announced today that the first infant was screened for the disease as part of the organization’s Newborn Screening Pilot. This pilot testing program was launched in collaboration with the American College of Medical Genetics and Genomics (ACMG) and New York State.
According to Pat Furlong, PPMD’s founding president and CEO, PPMD has been exploring newborn screening options for some time, and for the last five years has led a national effort to build a newborn screening infrastructure for Duchenne in the U.S., aimed at developing evidentiary support for Duchenne newborn screening.
“This is a hopeful time in Duchenne therapy development,” Furlong said. “We have a robust experimental therapy pipeline targeting multiple physiological pathways and multiple Duchenne product reviews currently underway. Yet it is believed that therapeutic interventions will be optimally effective the earlier they can be offered. It is the goal of PPMD and the Duchenne community to help eliminate the diagnostic delay in Duchenne through a public health program that includes newborn screening. We are grateful to all of our collaborators, ACMG, through the NIH-funded Newborn Screening Translational Research Network (NBSTRN), and the state of New York for helping us launch this pilot.”
The pilot program – designed to set up, validate and conduct a consented pilot screen for infants born at select hospitals in New York – will utilize tools, resources and expertise at PPMD, NBSTRN and the New York State Department of Health. The goal is to prevent families from experiencing an unnecessary diagnostic odyssey, and to ensure that every family receives timely, supportive and accurate resources at the time of diagnosis.
The program is being funded and led by a consortium of Duchenne industry partners. Consortium members include PTC Therapeutics, Sarepta Therapeutics, PerkinElmer, Solid Biosciences, Wave Life Sciences, Pfizer, Inc. and PPMD. Also guiding the pilot is a Steering Committee comprised of representatives from health care professional groups and representatives from key Duchenne stakeholder communities, including the American Academy of Pediatrics, the Centers for Disease Control and Prevention, the EveryLife Foundation and the Genetic Alliance’s Expecting Health.
“We are excited to contribute to this ground-breaking effort to determine the benefit of screening newborns for Duchenne. An important goal for the NBSTRN is to facilitate research to establish the evidence base for conditions to be considered for nationwide screening. During this pilot the NBSTRN will facilitate the collection of longitudinal health data from the clinicians caring for the diagnosed newborns and enable the newborns’ parents to share their experiences,” reported Dr. Amy Brower, associate project director of ACMG’s NBSTRN.
Building on work led by Dr. Jerry Mendell in the Ohio State Newborn Screening Pilot which concluded in 2012, PPMD endeavored to learn from that pilot’s best practices and refine the systems further so that they could be replicated in a state with a high birthrate – and eventually nationwide. In Mendell’s study, nearly 60,000 infants were screened. Six children with Duchenne were positively identified, establishing evidence for a two-tier screen at birth for Duchenne within the U.S. newborn screening system.
“PPMD convened experts and established the partnerships required to research, pilot, and implement nationwide newborn screening for Duchenne. This included the expertise and input of experts and leaders within federal agencies, newborn screening advocacy groups, the broader newborn screening community, and the Duchenne community,” explained Annie Kennedy, PPMD’s senior vice president of Legislation & Public Policy, who is leading this effort for the organization.
“Our efforts have also included an extensive collaboration with the world’s leading scientific and technology developers to identify and refine the screening tests used in Duchenne newborn screening,” she continued. “Based on the experience of the NBS programs throughout the world, our efforts have included a study to determine which approach to screening has appropriate analytical/clinical validity and utility for use by a public health laboratory. These efforts were conducted in collaboration with the California Department of Health, PerkinElmer, and several of PPMD’s Certified Duchenne Care Centers in California (UC Davis, UCLA, Stanford, and UCSF).”
“We have also collaborated with the CDC and the American Academy of Pediatrics (AAP) to develop diagnostic tools and resources for primary care providers and families,” noted Kennedy. “We are delighted that the yield from these efforts will now be applied to this pilot in New York, a high birth-rate state.”
Aside from the pilot program, PPMD’s newborn screening agenda includes work on the reauthorization of the Newborn Screening Saves Lives Act. PPMD also engages with the federal Advisory Committee on Heritable Disorders for Newborns and Children and leads the National Duchenne Newborn Screening Initiative, which has included development of published care standards for newborns, ethical considerations for Duchenne newborn screening and the publication of an article in the International Journal of Neonatal Screening.
“We are exceptionally grateful to the families, experts, and partners who have helped us to get to where we are today – our first newborn screened for Duchenne. Obviously no one wants their child to be diagnosed with Duchenne muscular dystrophy,” Furlong added. “But I am a firm believer that knowledge is power in our fight to end the progression of this deadly disorder. Early diagnosis will mean early intervention. Today is an important moment in our community’s history and we look forward to further developing and expanding this pilot with New York.”

DDNews Staff

Subscribe to Newsletter
Subscribe to our eNewsletters

Stay connected with all of the latest from Drug Discovery News.

March 2024 Issue Front Cover

Latest Issue  

• Volume 20 • Issue 2 • March 2024

March 2024

March 2024 Issue