Even within companies, the same cycles occur, as therapeuticcategories or drug families show so much hope as the next great panacea, onlyto see their fortunes fluctuate as more data comes in, or newer, shiniercandidates come out of discovery (see my commentary from the April 2013 issueof
DDNEWS, "An aside on side effects").
I'm not suggesting we can't take inspiration from successstories, but I think we need to temper that inspiration with a reminder thatsuccess can be measured in several different ways. One such way is longevity,and that is where most of the sexiest success stories tend to fall apart.
Rather than solely learn the lessons from the front end ofthe success stories, should we not also try to learn the lessons from the sometimes-demoralizingback end? It would be interesting to re-examine the stories from
DDNEWS' first year—or any otherpublication's—and see how those stories panned out, as well as lessons learned.(And no, I'm not offering to do it.)
The problem with the dolphin anecdote, for those who haven'talready figured it out?
We will almost never hear about the times the dolphinspushed the stranded seafarers further out to sea rather than to shore, becausethose people probably drowned. Thus, the anecdotal evidence is skewed in favorof success stories.
Willisis the features editor of DDNEWS. He has worked at both endsof the pharmaceutical industry, from basic research to marketing, and haswritten about biomedical science for almost two decades.