AI|ffinity
AI|ffinity is a spin-off of the Central European Institute of Technology (CEITEC) of Masaryk University with facilities both in Brno and Prague. The company has developed a unique technology platform that integrates NMR, AI, and Cheminformatics to advance drug discovery and protein engineering. The platform consists of deepHitMiner®, a deep learning software employing ultrafast NMR data to screen virtually and select diverse hit candidates or create them de novo. 4D-GRAPHS® is a machine learning software for automatic chemical shift assignment and structure determination from 3D, 4D, and 5D NMR spectra that enhances the analysis of IDPs and pushes the size boundaries of NMR to proteins above 20 kDa.Content by AI|ffinity
| 2 min read
A breakthrough from AI|ffinity and NexMR was achieved with a 100-fold affinity improvement in the initial round of drug discovery using ultrafast NMR screening and AI-driven lead generation against intrinsically disordered protein targets.
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